Drug Information

Drug General Information
Drug ID
D0Q8UV
Former ID
DNC011729
Drug Name
RO-145975
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534008]
Structure
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2D MOL

3D MOL
Formula
C17H16ClN3O3
Canonical SMILES
CCOC(=O)C1=C2C3CCCN3C(=O)C4=C(N2C=N1)C=CC(=C4)Cl
InChI
1S/C17H16ClN3O3/c1-2-24-17(23)14-15-13-4-3-7-20(13)16(22)11-8-10(18)5-6-12(11)21(15)9-19-14/h5-6,8-9,13H,2-4,7H2,1H3
InChIKey
GXXNSEYTZVNYNW-UHFFFAOYSA-N
PubChem Compound ID
623268
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor Target Info Inhibitor [534008]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [534008]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [534008]
Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [534008]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP706:SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 534008J Med Chem. 1993 Apr 16;36(8):1001-6.Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors.
Ref 534008J Med Chem. 1993 Apr 16;36(8):1001-6.Synthesis and evaluation of imidazo[1,5-a][1,4]benzodiazepine esters with high affinities and selectivities at "diazepam-insensitive" benzodiazepine receptors.

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