Drug General Information
Drug ID	D0Q9EV
Drug Name	lifitegrast
Synonyms	SAR-1118; SAR-1119; SHP606; SPD606; Xiidra
Drug Type	Small molecular drug
Indication	Dry eye disease [ICD9: 370.33; ICD10:H16.229]		Approved	[889440]
Company	Shire Pharmaceuticals
Structure		Download 2D MOL 3D MOL
Formula	C29H24Cl2N2O7S
PubChem Compound ID	11965427
Target and Pathway
Target(s)	Lymphocyte function-associated antigen 1	Target Info	Modulator	[889440]
KEGG Pathway	Rap1 signaling pathway
	Cell adhesion molecules (CAMs)
	Natural killer cell mediated cytotoxicity
	Leukocyte transendothelial migration
	Regulation of actin cytoskeleton
	Malaria
	Staphylococcus aureus infection
	HTLV-I infection
	Epstein-Barr virus infection
	Rheumatoid arthritis
	Viral myocarditis
NetPath Pathway	TCR Signaling Pathway
	RANKL Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
	Integrin signalling pathway
Pathway Interaction Database	Integrin family cell surface interactions
	Beta2 integrin cell surface interactions
	CXCR3-mediated signaling events
Reactome	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Cell surface interactions at the vascular wall
	Integrin cell surface interactions
WikiPathways	Focal Adhesion
	Integrin-mediated Cell Adhesion
	Integrin cell surface interactions
	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Cell surface interactions at the vascular wall
References
Ref 889440	2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. doi: 10.1038/nrd.2017.14.
Ref 889440	2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. doi: 10.1038/nrd.2017.14.

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