Drug Information

Drug General Information
Drug ID
D0QJ6L
Former ID
DIB001998
Drug Name
Demogastrin
Synonyms
Demogastrin; Technetium-99m-Demogastrin 2; Cholecystokinin-2 receptor/gastrin-R binding radiolabeled minigastrinanalogue (medullary thyroid cancer), Biomedica Life Science; 99mTc-Demogastrin 2; 99mTc-N4-Gly-(D)Glu-(Glu)5-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2
Indication Medullary thyroid cancer [ICD9: 193; ICD10:C73] Phase 1 [549943]
Company
Biomedica Life Sciences SA
Structure
Download
2D MOL

3D MOL
Canonical SMILES
[99Tc+3](=O)=O.N([C@H](C(=O)N)Cc1ccccc1)C(=O)[C@@H](NC(<br />=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H]<br />(NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC<br />(=O)[C@@H](NC(=O)[C@H](NC(=O)CNC(=O)C(C[N-]CCN)C[N-]CCN<br />)CCC(=O)O)CCC(=O)O)CCC(=O)O)CCC(=O)O)CCC(=O)O)CCC(=O)O)<br />C)Cc1ccc(cc1)O)Cc1c[nH]c2c1cccc2)CCSC)CC(=O)O
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info Modulator [525622]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 54994399mTc-Demogastrin 2 for CCK 2-receptor scintigraphy in medullary thyroid carcinoma. J Nucl Med. 2008; 49 (Supplement 1):115P.
Ref 525622Demonstration of new sites of expression of the CCK-B/gastrin receptor in pancreatic acinar AR42J cells using immunoelectron microscopy. Regul Pept. 1999 Oct 22;84(1-3):81-9.

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