Drug General Information
Drug ID
Former ID
Drug Name
Drug Type
Small molecular drug
Indication Trematode infection [ICD10:B66.9] Withdrawn from market [539482], [551871]


CAS Number
CAS 97-18-7
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
D10AB01; P02BX01
Target and Pathway
Target(s) Estrogen receptor Target Info Inhibitor [531262]
Calpain Target Info Inhibitor [531262]
Estrogen receptor beta Target Info Inhibitor [531262]
Induced myeloid leukemia cell differentiation protein Mcl-1 Target Info Inhibitor [531262]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Proteoglycans in cancerhsa04141:Protein processing in endoplasmic reticulum
Alzheimer's diseasehsa04915:Estrogen signaling pathway
Prolactin signaling pathwayhsa04151:PI3K-Akt signaling pathway
MicroRNAs in cancer
NetPath Pathway FSH Signaling Pathway
EGFR1 Signaling Pathway
RANKL Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
CCKR signaling map ST
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
Plasma membrane estrogen receptor signaling
LKB1 signaling events
Regulation of Telomerase
ATF-2 transcription factor network
AP-1 transcription factor network
FOXM1 transcription factor network
Validated nuclear estrogen receptor alpha network
Signaling mediated by p38-alpha and p38-beta
FOXA1 transcription factor networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha networke2f_pathway:E2F transcription factor network
Direct p53 effectors
IL6-mediated signaling events
HIF-1-alpha transcription factor network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathwayR-HSA-1474228:Degradation of the extracellular matrixR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways Estrogen signaling pathway
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
Signaling by ERBB4
Integrated Pancreatic Cancer Pathway
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
Integrated Breast Cancer Pathway
Nuclear ReceptorsWP306:Focal Adhesion
Alzheimers Disease
Integrin-mediated Cell AdhesionWP706:SIDS Susceptibility Pathways
Ovarian Infertility Genes
Nuclear ReceptorsWP254:Apoptosis
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
Apoptosis Modulation and Signaling
Ref 539482(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2338).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).

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