Drug Information
Drug General Information | |||||
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Drug ID |
D0R0FE
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Former ID |
DAP000040
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Drug Name |
Verapamil
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Synonyms |
Arpamyl; Calan; Calcan; Cordilox; Dexverapamil; Dilacoran; Drosteakard; Iproveratril; Isoptimo; Isoptin; Isotopin; Vasolan; Veracim; Verapamilo; Verapamilum; Veraptin; Verexamil; Bosoptin (TN); Calan (TN); D-365; Isoptin (TN); Verapamilo [INN-Spanish]; Verapamilum [INN-Latin]; Verelan (TN); CP-16533-1; Covera-HS (TN); Verapamil (USAN/INN); Verapamil [USAN:BAN:INN]; Verapamil [USAN:INN:BAN]; Alpha-((N-Methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile; Alpha-Isopropyl-alpha-((N-methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile; Alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)-methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile; (+-)-Verapamil; (+/-)-VERAPAMIL; (1)-3-(3,4-Dimethoxyphenyl)-6-((5,6-dimethoxyphenethyl)methylamino)hexane-3-carbonitrile; 2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-(1-methylethyl) pentanenitrile; 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile; 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile; 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile; 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile; Verapamil (Na-Ca chanel blocker)
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Drug Type |
Small molecular drug
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Therapeutic Class |
Analgesics
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Company |
Pfizer Inc
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Structure |
Download2D MOL |
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Formula |
C27H38N2O4
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InChI |
InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3
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InChIKey |
SGTNSNPWRIOYBX-UHFFFAOYSA-N
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CAS Number |
CAS 52-53-9
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PubChem Compound ID | |||||
PubChem Substance ID |
9397, 598709, 3153219, 5635244, 7849415, 7980877, 8151673, 10525256, 11120305, 11120793, 11121281, 11121578, 11122058, 11335574, 11360813, 11362647, 11364755, 11365209, 11367317, 11367771, 11369879, 11370565, 11370566, 11372920, 11373372, 11374511, 11375479, 11375933, 11378044, 11424501, 11461785, 11466169, 11467289, 11485556, 11485917, 11489556, 11492721, 14784349, 26751824, 26751825, 29221683, 46508158, 47217025, 47291346, 47291347, 47440510, 47515567, 47589211, 47885631, 48035377
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ChEBI ID |
ChEBI:9948
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SuperDrug ATC ID |
C08DA01
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SuperDrug CAS ID |
cas=000052539
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Target and Pathway | |||||
Target(s) | Voltage-dependent T-type calcium channel alpha-1G subunit | Target Info | Blocker | [536067], [538057] | |
Pathway Interaction Database | Regulation of nuclear beta catenin signaling and target gene transcription | ||||
PathWhiz Pathway | Muscle/Heart Contraction | ||||
Reactome | NCAM1 interactions | ||||
References | |||||
Ref 536619 | Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis. PLoS Biol. 2008 Feb;6(2):e26. | ||||
Ref 539535 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2406). |
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