Drug Information

Drug General Information
Drug ID
D0R0IB
Former ID
DIB021193
Drug Name
VU0463597
Synonyms
ML289; (R)-VU0463597
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541395]
Structure
Download
2D MOL
Formula
C22H23NO3
InChI
InChI=1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m1/s1
InChIKey
VSLWUPHHCFQTDB-LJQANCHMSA-N
PubChem Compound ID
56587994
PubChem Substance ID
134214276, 134418964, 144095597, 152191989, 163325426, 163350110, 178102846, 196376148, 208265441, 223641906, 241377277, 249691361, 252158505, 252450299
Target and Pathway
Target(s) Metabotropic glutamate receptor3 Target Info Modulator (allosteric modulator) [531911]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 541395(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6225).
Ref 531911Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3921-5.

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