Drug Information

Drug General Information
Drug ID
D0R2KV
Former ID
DCL000757
Drug Name
CP-316,311
Synonyms
CP-316311
Drug Type
Small molecular drug
Indication Major depressive disorder; Severe mood disorder [ICD9: 296, 296.2, 296.3; ICD10:F30-F39, F32, F33] Discontinued in Phase 2 [546625]
Company
Pfizer
Structure
Download
2D MOL

3D MOL
Formula
C21H29NO2
Canonical SMILES
CCC(CC)OC1=CC(=NC(=C1C)OC2=C(C=C(C=C2C)C)C)C
InChI
1S/C21H29NO2/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3
InChIKey
ZSEJGVQTBLJRCQ-UHFFFAOYSA-N
PubChem Compound ID
9818802
PubChem Substance ID
14777353, 24122818, 44854764, 49689007, 74515667, 103578386, 129947489, 134345509, 142534100, 162448223, 163679262, 223924812, 229261895
Target and Pathway
Target(s) Corticotropin releasing factor receptor 1 Target Info Antagonist [536580]
KEGG Pathway Neuroactive ligand-receptor interaction
Long-term depression
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Cortocotropin releasing factor receptor signaling pathway
Reactome Class B/2 (Secretin family receptors)
G alpha (s) signalling events
WikiPathways GPCRs, Class B Secretin-like
Myometrial Relaxation and Contraction Pathways
Corticotropin-releasing hormone
GPCR ligand binding
GPCR downstream signaling
References
Ref 546625Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009248)
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.

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