Drug General Information
Drug ID	D0R3MB
Former ID	DNC003663
Drug Name	6-(Benzofuran-2-sulfonyl)-2H-pyridazin-3-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527771]
Structure		Download 2D MOL 3D MOL
Formula	C12H8N2O4S
Canonical SMILES	C1=CC=C2C(=C1)C=C(O2)S(=O)(=O)C3=NNC(=O)C=C3
InChI	1S/C12H8N2O4S/c15-10-5-6-11(14-13-10)19(16,17)12-7-8-3-1-2-4-9(8)18-12/h1-7H,(H,13,15)
InChIKey	RBZSSTPBYFHRSR-UHFFFAOYSA-N
PubChem Compound ID	11807954
Target and Pathway
Target(s)	Aldose reductase	Target Info	Inhibitor	[527771]
BioCyc Pathway	Methylglyoxal degradation III
	Acetone degradation I (to methylglyoxal)
KEGG Pathway	Pentose and glucuronate interconversions
	Fructose and mannose metabolism
	Galactose metabolism
	Glycerolipid metabolism
	Metabolic pathways
NetPath Pathway	IL1 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway	Fructose and Mannose Degradation
	Pyruvate Metabolism
	Pterine Biosynthesis
	Glycerolipid Metabolism
	Galactose Metabolism
WikiPathways	Metapathway biotransformation
	Polyol Pathway
	Metabolism of steroid hormones and vitamin D
References
Ref 527771	J Med Chem. 2005 Oct 6;48(20):6326-39.A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.
Ref 527771	J Med Chem. 2005 Oct 6;48(20):6326-39.A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.