Drug Information

Drug General Information
Drug ID
D0R3VL
Former ID
DIB010045
Drug Name
CCR4 antagonists
Synonyms
CCR4 antagonists (atopic dermatitis); RS-1154; RS-1269; CCR4 antagonists (atopic dermatitis), Daiichi Sankyo
Indication Atopic dermatitis [ICD9: 691.8, 692.9; ICD10:L00-L99] Investigative [552067]
Company
Daiichi Sankyo Co Ltd
Structure
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2D MOL

3D MOL
Canonical SMILES
C(=O)(c1cc(ccc1)NC(=O)C(C)C)NCC[C@]1(CN(CCO1)Cc1ccc(cc1<br />)c1ccncc1)c1ccccc1
Target and Pathway
Target(s) C-Cchemokine receptor type 4 Target Info Antagonist [543896]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Viral carcinogenesis
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 552067A novel CC chemokine receptor 4 antagonist RS-1269 inhibits ovalbumin-induced ear swelling and lipopolysaccharide-induced endotoxic shock in mice. Basic Clin Pharmacol Toxicol. 2010 Oct;107(4):793-7
Ref 543896(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 61).

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