Drug General Information
Drug ID	D0R4DK
Former ID	DNC010909
Drug Name	1-(1-phenyl-1H-tetrazol-5-ylthio)propan-2-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530901]
Structure		Download 2D MOL 3D MOL
Formula	C11H11N3OS
Canonical SMILES	CC(=O)CSC1=CN=NN1C2=CC=CC=C2
InChI	1S/C11H11N3OS/c1-9(15)8-16-11-7-12-13-14(11)10-5-3-2-4-6-10/h2-7H,8H2,1H3
InChIKey	ZEWXXPJFFAXSFB-UHFFFAOYSA-N
PubChem Compound ID	46890076
Target and Pathway
Target(s)	Corticosteroid 11-beta-dehydrogenase, isozyme 1	Target Info	Inhibitor	[530901]
KEGG Pathway	Steroid hormone biosynthesis
	Metabolism of xenobiotics by cytochrome P450
	Metabolic pathways
	Chemical carcinogenesis
NetPath Pathway	IL1 Signaling Pathway
	FSH Signaling Pathway
PathWhiz Pathway	Steroidogenesis
Reactome	Glucocorticoid biosynthesis
WikiPathways	Prostaglandin Synthesis and Regulation
	Metabolism of steroid hormones and vitamin D
	Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 530901	Bioorg Med Chem Lett. 2010 Jun 1;20(11):3265-71. Epub 2010 Apr 18.Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles.
Ref 530901	Bioorg Med Chem Lett. 2010 Jun 1;20(11):3265-71. Epub 2010 Apr 18.Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles.

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