Drug General Information
Drug ID	D0R5FH
Former ID	DIB019094
Drug Name	Quinoxaline1
Synonyms	quinoxaline1
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541231]
Structure		Download 2D MOL
Formula	C9H7N5
InChI	InChI=1S/C9H7N5/c10-8-7-9(14-13-8)12-6-4-2-1-3-5(6)11-7/h1-4H,(H3,10,12,13,14)
InChIKey	DWHVZCLBMTZRQM-UHFFFAOYSA-N
PubChem Compound ID	438981
PubChem Substance ID	582371, 5333485, 6711854, 11108319, 11114238, 11437952, 14720322, 15067061, 26758400, 36883279, 48317966, 76985091, 85788168, 91746526, 99302655, 103567265, 104619355, 132576526, 162023320, 162528221, 162874423, 163688436, 164780459, 172831861, 172836080, 175607463, 177748372, 178102570, 179236127, 223959984, 227610308, 241088291, 241375702, 243605574, 248594160, 252156200
Target and Pathway
Target(s)	Cell division protein kinase 5	Target Info	Inhibitor	[529213]
	Cell division control protein 2 homolog	Target Info	Inhibitor	[529213]
	Glycogen synthase kinase-3 beta	Target Info	Inhibitor	[529213]
KEGG Pathway	Axon guidance
	Alzheimer's disease
	Cocaine addictionhsa04110:Cell cycle
	Oocyte meiosis
	p53 signaling pathway
	Gap junction
	Progesterone-mediated oocyte maturation
	Herpes simplex infection
	Epstein-Barr virus infection
	Viral carcinogenesishsa04012:ErbB signaling pathway
	Chemokine signaling pathway
	Cell cycle
	PI3K-Akt signaling pathway
	Wnt signaling pathway
	Hedgehog signaling pathway
	Hippo signaling pathway
	Focal adhesion
	Signaling pathways regulating pluripotency of stem cells
	T cell receptor signaling pathway
	B cell receptor signaling pathway
	Neurotrophin signaling pathway
	Dopaminergic synapse
	Insulin signaling pathway
	Melanogenesis
	Prolactin signaling pathway
	Thyroid hormone signaling pathway
	Non-alcoholic fatty liver disease (NAFLD)
	Hepatitis C
	Measles
	Influenza A
	HTLV-I infection
	Pathways in cancer
	Colorectal cancer
	Endometrial cancer
	Prostate cancer
	Basal cell carcinoma
NetPath Pathway	EGFR1 Signaling Pathway
	TCR Signaling PathwayNetPath_21:RANKL Signaling Pathway
PANTHER Pathway	Axon guidance mediated by semaphorinsP00004:Alzheimer disease-presenilin pathway
	Angiogenesis
	Cadherin signaling pathway
	Hedgehog signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Insulin/IGF pathway-protein kinase B signaling cascade
	Interleukin signaling pathway
	PDGF signaling pathway
	PI3 kinase pathway
	Wnt signaling pathway
	Ras Pathway
	CCKR signaling map ST
Pathway Interaction Database	Reelin signaling pathway
	Glucocorticoid receptor regulatory network
	Lissencephaly gene (LIS1) in neuronal migration and development
	EPHA forward signaling
	Trk receptor signaling mediated by the MAPK pathwayp73pathway:p73 transcription factor network
	E2F transcription factor network
	PLK1 signaling events
	AP-1 transcription factor network
	FOXM1 transcription factor network
	Retinoic acid receptors-mediated signalinglysophospholipid_pathway:LPA receptor mediated events
	Degradation of beta catenin
	Presenilin action in Notch and Wnt signaling
	Integrin-linked kinase signaling
	CDC42 signaling events
	LKB1 signaling events
	Canonical Wnt signaling pathway
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	C-MYC pathway
	Regulation of Androgen receptor activity
	BMP receptor signaling
	Hedgehog signaling events mediated by Gli proteins
	Signaling events mediated by Stem cell factor receptor (c-Kit)
	Validated transcriptional targets of deltaNp63 isoforms
	Aurora A signaling
	Insulin-mediated glucose transport
	Class I PI3K signaling events mediated by Akt
	p53 pathway
	Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome	DARPP-32 events
	CRMPs in Sema3A signaling
	Factors involved in megakaryocyte development and platelet productionR-HSA-110056:MAPK3 (ERK1) activation
	E2F mediated regulation of DNA replication
	G0 and Early G1
	Cyclin B2 mediated events
	Golgi Cisternae Pericentriolar Stack Reorganization
	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
	Regulation of APC/C activators between G1/S and early anaphase
	Phosphorylation of the APC/C
	Phosphorylation of Emi1
	Condensation of Prophase Chromosomes
	MASTL Facilitates Mitotic Progression
	Resolution of Sister Chromatid Cohesion
	Condensation of Prometaphase Chromosomes
	Regulation of PLK1 Activity at G2/M Transition
	Activation of NIMA Kinases NEK9, NEK6, NEK7
	Loss of Nlp from mitotic centrosomes
	Recruitment of mitotic centrosome proteins and complexes
	Loss of proteins required for interphase microtubule organization?from the centrosome
	Recruitment of NuMA to mitotic centrosomes
	Depolymerisation of the Nuclear Lamina
	Anchoring of the basal body to the plasma membrane
	MAPK6/MAPK4 signaling
	G1/S-Specific Transcription
	Cyclin A/B1 associated events during G2/M transition
	G2/M DNA replication checkpoint
	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-195253:Degradation of beta-catenin by the destruction complex
	AKT phosphorylates targets in the cytosol
	Regulation of HSF1-mediated heat shock response
	Disassembly of the destruction complex and recruitment of AXIN to the membrane
	S33 mutants of beta-catenin aren't phosphorylated
	S37 mutants of beta-catenin aren't phosphorylated
	S45 mutants of beta-catenin aren't phosphorylated
	T41 mutants of beta-catenin aren't phosphorylated
	Degradation of GLI2 by the proteasome
	Constitutive Signaling by AKT1 E17K in Cancer
WikiPathways	DNA Damage Response
	BDNF signaling pathway
	Alzheimers Disease
	Opioid Signalling
	Semaphorin interactions
	Factors involved in megakaryocyte development and platelet production
	Nicotine Activity on Dopaminergic Neurons
	miRNA Regulation of DNA Damage ResponseWP707:DNA Damage Response
	G1 to S cell cycle control
	TGF beta Signaling Pathway
	PPAR Alpha Pathway
	MAP kinase activation in TLR cascade
	RAF/MAP kinase cascade
	Mitotic Prophase
	Mitotic Prometaphase
	BMI1
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Spinal Cord Injury
	Prostate Cancer
	Regulation of Microtubule Cytoskeleton
	Integrated Cancer pathway
	Mitotic G2-G2/M phases
	Mitotic G1-G1/S phases
	Cell Cycle
	APC/C-mediated degradation of cell cycle proteins
	Cell Cycle Checkpoints
	miRNA Regulation of DNA Damage ResponseWP710:DNA Damage Response (only ATM dependent)
	Senescence and Autophagy in Cancer
	Notch Signaling Pathway
	Glycogen Metabolism
	Insulin Signaling
	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	IL-6 signaling pathway
	Wnt Signaling Pathway Netpath
	Copper homeostasis
	Focal Adhesion
	Hair Follicle Development: Induction (Part 1 of 3)
	Cardiac Hypertrophic Response
	Degradation of beta-catenin by the destruction complex
	T-Cell Receptor and Co-stimulatory Signaling
	Cardiac Progenitor Differentiation
	Corticotropin-releasing hormone
	B Cell Receptor Signaling Pathway
	IL17 signaling pathway
	Neural Crest Differentiation
	IL-7 Signaling Pathway
	TWEAK Signaling Pathway
	Leptin signaling pathway
	MicroRNAs in cardiomyocyte hypertrophy
	Androgen receptor signaling pathway
	IL-5 Signaling Pathway
References
Ref 541231	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5947).
Ref 529213	Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. Epub 2007 Dec 11.A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

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