Drug General Information
Drug ID
D0R5KO
Former ID
DNC006689
Drug Name
C(his-D-phe-arg-trp-Ahx)
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528187]
Structure
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2D MOL

3D MOL

Formula
C38H49N11O5
Canonical SMILES
C1CCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC1)CC2=CNC3=<br />CC=CC=C32)CCCN=C(N)N)CC4=CC=CC=C4)CC5=CN=CN5
InChI
1S/C38H49N11O5/c39-38(40)43-17-9-14-29-35(52)49-31(19-25-21-44-28-13-7-6-12-27(25)28)34(51)42-16-8-2-5-15-33(50)46-32(20-26-22-41-23-45-26)37(54)48-30(36(53)47-29)18-24-10-3-1-4-11-24/h1,3-4,6-7,10-13,21-23,29-32,44H,2,5,8-9,14-20H2,(H,41,45)(H,42,51)(H,46,50)(H,47,53)(H,48,54)(H,49,52)(H4,39,40,43)/t29-,30+,31-,32+/m0/s1
InChIKey
NKDXCOMNRCSRHU-MLMSKLGMSA-N
PubChem Compound ID
Target and Pathway
Target(s) Melanocortin-4 receptor Target Info Inhibitor [528187]
KEGG Pathway Neuroactive ligand-receptor interaction
Pathway Interaction Database Syndecan-3-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 528187Bioorg Med Chem Lett. 2006 Jul 15;16(14):3723-6. Epub 2006 May 5.Design of cyclic peptides with agonist activity at melanocortin receptor-4.
Ref 528187Bioorg Med Chem Lett. 2006 Jul 15;16(14):3723-6. Epub 2006 May 5.Design of cyclic peptides with agonist activity at melanocortin receptor-4.

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