Drug Information

Drug General Information
Drug ID
D0R5ZR
Former ID
DNC010627
Drug Name
RO-320432
Drug Type
Small molecular drug
Indication Discovery agent Terminated [541291], [545975]
Structure
Download
2D MOL

3D MOL
Formula
C28H28N4O2
InChI
InChI=1S/C28H28N4O2/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34)/t17-/m0/s1
InChIKey
FXGHOAZJQNLNFD-KRWDZBQOSA-N
PubChem Compound ID
127757
PubChem Substance ID
10241852, 12014831, 14808691, 29306964, 50064488, 53789529, 57342310, 78835492, 103193742, 104124307, 104366557, 127912841, 134347832, 135082795, 142170444, 178102656, 180056919, 184594446, 227762906
Target and Pathway
Target(s) Protein kinase C, delta type Target Info Inhibitor [551264]
Protein kinase C, epsilon type Target Info Inhibitor [551264]
Protein kinase C, theta type Target Info Inhibitor [551264]
Protein kinase C, zeta type Target Info Inhibitor [551264]
Protein kinase C, beta type Target Info Inhibitor [551264]
Protein kinase C, alpha type Target Info Inhibitor [551264]
Glycogen synthase kinase-3 beta Target Info Inhibitor [530695]
Protein kinase C gamma type Target Info Inhibitor [551264]
KEGG Pathway Chemokine signaling pathway
Vascular smooth muscle contraction
Tight junction
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Estrogen signaling pathway
Type II diabetes mellitushsa04022:cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Type II diabetes mellitus
MicroRNAs in cancerhsa04064:NF-kappa B signaling pathway
T cell receptor signaling pathway
Adipocytokine signaling pathway
Measleshsa04015:Rap1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Hippo signaling pathway
Platelet activation
Insulin signaling pathway
Type II diabetes mellitushsa04010:MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
Wnt signaling pathway
VEGF signaling pathway
Focal adhesion
Gap junction
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Leukocyte transendothelial migration
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Insulin secretion
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Carbohydrate digestion and absorption
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
Leishmaniasis
African trypanosomiasis
Amoebiasis
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
Adrenergic signaling in cardiomyocytes
Pathogenic Escherichia coli infection
Choline metabolism in cancerhsa04012:ErbB signaling pathway
Cell cycle
Hedgehog signaling pathway
Axon guidance
Signaling pathways regulating pluripotency of stem cells
Prolactin signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer's disease
Hepatitis C
Measles
HTLV-I infection
Epstein-Barr virus infection
Colorectal cancer
Endometrial cancer
Prostate cancer
Basal cell carcinomahsa04010:MAPK signaling pathway
Choline metabolism in cancer
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Alzheimer disease-amyloid secretase pathway
Angiogenesis
Apoptosis signaling pathway
B cell activation
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
VEGF signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
CCKR signaling map STP00002:Alpha adrenergic receptor signaling pathway
Inflammation mediated by chemokine and cytokine signaling pathway
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
T cell activation
Thyrotropin-releasing hormone receptor signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Metabotropic glutamate receptor group I pathway
PDGF signaling pathway
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Cadherin signaling pathway
Hedgehog signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Insulin/IGF pathway-protein kinase B signaling cascade
Interleukin signaling pathway
PI3 kinase pathway
Ras Pathway
Pathway Interaction Database Endothelins
LPA receptor mediated events
Thromboxane A2 receptor signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IGF1 pathway
Ceramide signaling pathway
IFN-gamma pathway
ErbB1 downstream signaling
Syndecan-4-mediated signaling events
IL6-mediated signaling events
PDGFR-beta signaling pathway
Hedgehog signaling events mediated by Gli proteins
Signaling events mediated by VEGFR1 and VEGFR2
PAR1-mediated thrombin signaling events
Syndecan-2-mediated signaling events
Validated transcriptional targets of TAp63 isoforms
p53 pathway
Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Alpha-synuclein signalingendothelinpathway:Endothelins
TCR signaling in na&#xef
LPA4-mediated signaling events
CDC42 signaling events
TCR signaling in na&#xef
IL2-mediated signaling events
IL8- and CXCR1-mediated signaling events
Regulation of Ras family activation
Downstream signaling in na&#xef
Endothelins
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
RhoA signaling pathway
Insulin Pathway
Noncanonical Wnt signaling pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
IL1-mediated signaling events
CXCR4-mediated signaling events
TNF receptor signaling pathway
IL2 signaling events mediated by PI3K
p75(NTR)-mediated signaling
amb2 Integrin signaling
Neurotrophic factor-mediated Trk receptor signaling
Nephrin/Neph1 signaling in the kidney podocyte
Insulin-mediated glucose transport
Regulation of Ras family activationfcer1pathway:Fc-epsilon receptor I signaling in mast cells
Ras signaling in the CD4+ TCR pathway
JNK signaling in the CD4+ TCR pathway
Canonical NF-kappaB pathway
Signaling events regulated by Ret tyrosine kinase
mTOR signaling pathway
ATF-2 transcription factor network
Retinoic acid receptors-mediated signaling
IL8- and CXCR2-mediated signaling events
VEGFR1 specific signals
a6b1 and a6b4 Integrin signaling
LPA receptor mediated events
Degradation of beta catenin
Reelin signaling pathway
Presenilin action in Notch and Wnt signaling
Integrin-linked kinase signaling
LKB1 signaling events
Canonical Wnt signaling pathway
Glucocorticoid receptor regulatory network
C-MYC pathway
Regulation of Androgen receptor activity
BMP receptor signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
Validated transcriptional targets of deltaNp63 isoforms
Aurora A signaling
Class I PI3K signaling events mediated by Akt
Trk receptor signaling mediated by PI3K and PLC-gammaendothelinpathway:Endothelins
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Activation of PKC through G protein coupled receptor
Reactome Apoptotic cleavage of cellular proteins
Calmodulin induced events
Effects of PIP2 hydrolysis
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling events
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
Interferon gamma signalingR-HSA-114508:Effects of PIP2 hydrolysis
G alpha (z) signalling eventsR-HSA-111465:Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascade
FCERI mediated NF-kB activation
G alpha (z) signalling eventsR-HSA-114604:GPVI-mediated activation cascade
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
VEGFR2 mediated cell proliferationR-HSA-114516:Disinhibition of SNARE formation
Activation of NF-kappaB in B cells
Trafficking of GluR2-containing AMPA receptors
Depolymerisation of the Nuclear Lamina
WNT5A-dependent internalization of FZD4
Response to elevated platelet cytosolic Ca2+R-HSA-111933:Calmodulin induced events
Disinhibition of SNARE formation
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Syndecan interactions
Acetylcholine regulates insulin secretion
Ca2+ pathway
Response to elevated platelet cytosolic Ca2+R-HSA-195253:Degradation of beta-catenin by the destruction complex
AKT phosphorylates targets in the cytosol
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
Degradation of GLI2 by the proteasome
Constitutive Signaling by AKT1 E17K in CancerR-HSA-111933:Calmodulin induced events
Response to elevated platelet cytosolic Ca2+
WikiPathways TCR Signaling Pathway
Type II interferon signaling (IFNG)
Calcium Regulation in the Cardiac Cell
Insulin Signaling
EGF/EGFR Signaling Pathway
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
MAPK Signaling Pathway
IL-6 signaling pathway
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
DAG and IP3 signaling
Alpha 6 Beta 4 signaling pathway
BDNF signaling pathway
Oncostatin M Signaling Pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
B Cell Receptor Signaling Pathway
Signaling Pathways in Glioblastoma
miRs in Muscle Cell Differentiation
Opioid Signalling
GPCR downstream signaling
Effects of PIP2 hydrolysis
Apoptotic execution phase
Type II diabetes mellitusWP666:Hypothetical Network for Drug Addiction
Physiological and Pathological Hypertrophy of the HeartWP69:TCR Signaling Pathway
Fc epsilon receptor (FCERI) signaling
TCR signaling
Netrin-1 signaling
Apoptotic execution phaseWP536:Calcium Regulation in the Cardiac Cell
Signaling by TGF-beta Receptor Complex
Allograft Rejection
TNF alpha Signaling Pathway
IL-1 signaling pathway
GPVI-mediated activation cascade
Type II diabetes mellitusWP536:Calcium Regulation in the Cardiac Cell
Wnt Signaling Pathway Netpath
Kit receptor signaling pathway
Signaling by the B Cell Receptor (BCR)
Response to elevated platelet cytosolic Ca2+
MicroRNAs in cardiomyocyte hypertrophy
Physiological and Pathological Hypertrophy of the HeartWP673:ErbB Signaling Pathway
Transcriptional activation by NRF2
Human Complement System
Cardiac Hypertrophic Response
Syndecan interactions
Signaling by SCF-KIT
Gastrin-CREB signalling pathway via PKC and MAPK
T-Cell Receptor and Co-stimulatory Signaling
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Pathogenic Escherichia coli infection
Endothelin Pathways
Regulation of Microtubule Cytoskeleton
FSH signaling pathway
Integration of energy metabolism
TOR SignalingWP710:DNA Damage Response (only ATM dependent)
Senescence and Autophagy in Cancer
Notch Signaling Pathway
Glycogen Metabolism
Copper homeostasis
Focal Adhesion
Hair Follicle Development: Induction (Part 1 of 3)
Degradation of beta-catenin by the destruction complex
Cardiac Progenitor Differentiation
IL17 signaling pathway
Neural Crest Differentiation
Alzheimers Disease
IL-7 Signaling Pathway
TWEAK Signaling Pathway
Leptin signaling pathway
Semaphorin interactions
Cell Cycle
Androgen receptor signaling pathway
IL-5 Signaling PathwayWP536:Calcium Regulation in the Cardiac Cell
References
Ref 541291(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6034).
Ref 545975Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005586)
Ref 530695Bioorg Med Chem Lett. 2010 Mar 1;20(5):1693-6. Epub 2010 Jan 25.Discovery of potent and bioavailable GSK-3beta inhibitors.
Ref 551264Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994).

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