Drug General Information
Drug ID	D0R6ZS
Former ID	DNC014279
Drug Name	N-(3-bromophenyl)-6-chloroquinazolin-4-amine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530473]
Structure		Download 2D MOL 3D MOL
Formula	C14H9BrClN3
Canonical SMILES	C1=CC(=CC(=C1)Br)NC2=NC=NC3=C2C=C(C=C3)Cl
InChI	1S/C14H9BrClN3/c15-9-2-1-3-11(6-9)19-14-12-7-10(16)4-5-13(12)17-8-18-14/h1-8H,(H,17,18,19)
InChIKey	NBEFPXHBLZGXNK-UHFFFAOYSA-N
PubChem Compound ID	11056756
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Inhibitor	[530473]
	Metabotropicglutamate receptor 1	Target Info	Inhibitor	[530473]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's diseasehsa04020:Calcium signaling pathway
	FoxO signaling pathway
	Long-term depression
	Estrogen signaling pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signalingP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-416476:G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
	GPCR downstream signaling
	GPCRs, Other
References
Ref 530473	Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. Epub 2009 Oct 9.Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.
Ref 530473	Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. Epub 2009 Oct 9.Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.

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