Drug Information

Drug General Information
Drug ID
D0R7SM
Former ID
DIB019163
Drug Name
compound (S)-3h
Synonyms
2-benzylpyrridine-substituted aryloxypropanol analogue
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527418], [542127]
Structure
Download
2D MOL
Formula
C21H23ClN2O2
InChI
InChI=1S/C21H23ClN2O2/c22-20-9-4-10-21(19(20)13-23)26-15-18(25)14-24-11-5-8-17(24)12-16-6-2-1-3-7-16/h1-4,6-7,9-10,17-18,25H,5,8,11-12,14-15H2/t17-,18+/m0/s1
InChIKey
HSTMYWDURDPUMY-ZWKOTPCHSA-N
PubChem Compound ID
11710462
PubChem Substance ID
16815304, 77037116, 103443171, 135650122
Target and Pathway
Target(s) Extracellular calcium-sensing receptor Target Info Antagonist [527418]
Pathway Interaction Database E-cadherin signaling in keratinocytes
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 527418Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1225-8.
Ref 542127(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 712).
Ref 527418Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1225-8.

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