TTD | Drug: D0R8DO

Drug General Information
Drug ID	D0R8DO
Former ID	DNC009731
Drug Name	1-Benzyl-4-(4-phenylpiperazin-1-yl)phthalazine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530165]
Structure		Download 2D MOL 3D MOL
Formula	C25H24N4
Canonical SMILES	C1CN(CCN1C2=CC=CC=C2)C3=NN=C(C4=CC=CC=C43)CC5=CC=CC=C5
InChI	1S/C25H24N4/c1-3-9-20(10-4-1)19-24-22-13-7-8-14-23(22)25(27-26-24)29-17-15-28(16-18-29)21-11-5-2-6-12-21/h1-14H,15-19H2
InChIKey	PMNLMFUHSIYHHB-UHFFFAOYSA-N
PubChem Compound ID	6404568
Target and Pathway
Target(s)	smoothened receptor	Target Info	Inhibitor	[530165]
KEGG Pathway	Hedgehog signaling pathway
	Pathways in cancer
	Proteoglycans in cancer
	Basal cell carcinoma
PANTHER Pathway	Hedgehog signaling pathway
Pathway Interaction Database	Signaling events mediated by the Hedgehog family
Pathway Interaction Database	Hedgehog signaling events mediated by Gli proteins
Reactome	Class B/2 (Secretin family receptors)
	Hedgehog 'off' state
	Activation of SMO
WikiPathways	Hedgehog Signaling Pathway
	Hair Follicle Development: Organogenesis (Part 2 of 3)
	Hair Follicle Development: Induction (Part 1 of 3)
	Integrated Pancreatic Cancer Pathway
	GPCR ligand binding
	GPCRs, Other
References
Ref 530165	J Med Chem. 2009 Jul 9;52(13):3954-68.1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity.
Ref 530165	J Med Chem. 2009 Jul 9;52(13):3954-68.1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity.

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Drug Information