Drug Information

Drug General Information
Drug ID
D0R9ZB
Former ID
DAP000327
Drug Name
Propiomazine
Synonyms
Phenoctyl; Propiomazina; Propiomazinum; Propionylpromethazine; Dorevan (TN); Dorevane (TN); Indorm (TN); Largon (TN); Propavan (TN); Propiomazina [INN-Spanish]; Propiomazinum [INN-Latin]; Serentin (TN); Wy-1359; Propiomazine (USAN/INN); Propiomazine [USAN:BAN:INN]; Propiomazine [USAN:INN:BAN]; 1-(10-(2-(Dimethylamino)propyl)phenothiazin-2-yl)-1-propanone; 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one; 1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}propan-1-one; 10-(2-Dimethylaminopropyl)-2-propionylphenothiazine; 10-Dimethylaminoisopropyl-2-propionylphenothiazine; 2-Propionyl-10-(2-(dimethylamino)propyl)phenothiazine; 3-Propionyl-10-dimethylaminoisopropylphenothiazine
Drug Type
Small molecular drug
Indication Insomnia; Anxiety disorder [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52, 300, 311; ICD10:F51.0, G47.0, F32, F40-F42] Approved [538458], [542304], [551871]
Therapeutic Class
Sedatives and Hypnotics
Company
Hikma Maple Ltd
Structure
Download
2D MOL

3D MOL
Formula
C20H24N2OS
InChI
InChI=1S/C20H24N2OS/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20/h6-12,14H,5,13H2,1-4H3
InChIKey
UVOIBTBFPOZKGP-UHFFFAOYSA-N
CAS Number
CAS 362-29-8
PubChem Compound ID
4940
PubChem Substance ID
9609, 5371491, 7849420, 7980415, 8153047, 10520217, 11335471, 11360710, 11363766, 11366328, 11368890, 11371837, 11374140, 11377052, 11461682, 11484576, 11488746, 11490375, 11492306, 11494686, 14802382, 29224018, 46506205, 47216685, 47736372, 47959643, 48334386, 48416479, 50023903, 50123416, 50721675, 56352892, 57322540, 85209519, 85789212, 104307837, 124955689, 125823477, 129426836, 134337639, 134973797, 137009964, 140649124, 160964120, 162185625, 178103858, 179038464, 226471484, 241060511, 249935360
ChEBI ID
ChEBI:8491
SuperDrug ATC ID
N05CM06
SuperDrug CAS ID
cas=000362298
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [536316]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538458FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 012382.
Ref 542304(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7284).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536316How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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