TTD | Drug: D0RC0J

Drug General Information
Drug ID	D0RC0J
Former ID	DNCL003048
Drug Name	ABT-436
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Phase 2	[524149]
Company	Abbott Laboratories
Target and Pathway
Target(s)	Vasopressin V1b receptor	Target Info	Modulator	[544158]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
Reactome	Vasopressin-like receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 524149	ClinicalTrials.gov (NCT01741142) Efficacy and Safety Study of ABT-436 in Major Depressive Disorder. U.S. National Institutes of Health.
Ref 544158	The vasopressin Avprlb receptor: Molecular and pharmacological studies. Stress. 2011 January; 14(1): 98-115.

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Drug Information