TTD | Drug: D0RJ6R

Drug General Information
Drug ID	D0RJ6R
Former ID	DIB003815
Drug Name	Du-123015
Synonyms	Benzopyran piperazine derivative (5HT modulator, neurological disorders), Solvay
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Terminated	[550366]
Company	Solvay SA
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(=O)oc2c(cc1N)cccc2N1CCNCC1.Cl.O
Target and Pathway
Target(s)	5-hydroxytryptamine 1A receptor	Target Info	Modulator	[550367]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
Reactome	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 550366	Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT1A agonist in rat models of ischaemic stroke. BMC Neuroscience 2009, 10:82.
Ref 550367	Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT1A agonist in rat models of ischaemic stroke. BMC Neuroscience 2009, 10:82.

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Drug Information