| Drug General Information |
| Drug ID |
D0RR4T
|
| Former ID |
DIB016465
|
| Drug Name |
GI-270384X
|
| Synonyms |
270384
|
| Indication |
Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51]
|
Terminated |
[1]
|
|---|
| Company |
GlaxoSmithKline Inc
|
| Target and Pathway |
| Target(s) |
ICAM-1 |
Target Info |
Modulator |
[1]
|
|---|
| E-selectin |
Target Info |
Modulator |
[1]
|
|
KEGG Pathway
|
NF-kappa B signaling pathway
|
|
Cell adhesion molecules (CAMs)
|
|
Natural killer cell mediated cytotoxicity
|
|
TNF signaling pathway
|
|
Leukocyte transendothelial migration
|
|
African trypanosomiasis
|
|
Malaria
|
|
Staphylococcus aureus infection
|
|
Influenza A
|
|
HTLV-I infection
|
|
Epstein-Barr virus infection
|
|
Rheumatoid arthritis
|
|
Viral myocarditishsa04514:Cell adhesion molecules (CAMs)
|
|
NetPath Pathway
|
IL5 Signaling Pathway
|
|
IL1 Signaling Pathway
|
|
TSH Signaling Pathway
|
|
IL6 Signaling Pathway
|
|
IL2 Signaling Pathway
|
|
ID Signaling Pathway
|
|
TWEAK Signaling Pathway
|
|
RANKL Signaling Pathway
|
|
TNFalpha Signaling PathwayNetPath_17:IL5 Signaling Pathway
|
|
IL4 Signaling Pathway
|
|
TNFalpha Signaling Pathway
|
|
Pathway Interaction Database
|
Thromboxane A2 receptor signaling
|
|
Glucocorticoid receptor regulatory network
|
|
amb2 Integrin signaling
|
|
Beta2 integrin cell surface interactionstxa2pathway:Thromboxane A2 receptor signaling
|
|
ATF-2 transcription factor network
|
|
Reactome
|
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
|
|
Integrin cell surface interactions
|
|
Interferon gamma signalingR-HSA-202733:Cell surface interactions at the vascular wall
|
|
WikiPathways
|
Type II interferon signaling (IFNG)
|
|
IL1 and megakaryotyces in obesity
|
|
Human Complement System
|
|
Spinal Cord Injury
|
|
Interleukin-11 Signaling Pathway
|
|
RANKL/RANK Signaling Pathway
|
|
Integrin cell surface interactions
|
|
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
|
|
Folate Metabolism
|
|
Vitamin B12 Metabolism
|
|
Selenium Micronutrient NetworkWP2806:Human Complement System
|
|
TNF alpha Signaling Pathway
|
|
Cell surface interactions at the vascular wall
|
| References |
| REF 1 | Inhibition of endothelial cell adhesion molecule expression improves colonic hyperalgaesia. Neurogastroenterol Motil. 2009 Feb;21(2):189-96. |
|---|
