TTD | Drug: D0S0QY

Drug General Information
Drug ID	D0S0QY
Former ID	DIB021095
Drug Name	TUG-770
Synonyms	TUG770
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541617]
Structure		Download 2D MOL
Formula	C19H14FNO2
InChI	InChI=1S/C19H14FNO2/c20-18-13-14(6-8-17(18)9-10-19(22)23)5-7-15-3-1-2-4-16(15)11-12-21/h1-4,6,8,13H,9-11H2,(H,22,23)
InChIKey	KIZUBVPJNPVIIN-UHFFFAOYSA-N
PubChem Compound ID	66553168
PubChem Substance ID	152159727, 164045803, 172821393, 174511772, 175446612, 178103097, 186022507, 210275289, 210280938, 223392190, 237990961, 242060076
Target and Pathway
Target(s)	GPR40	Target Info	Agonist	[532363]
KEGG Pathway	Insulin secretion
Reactome	G alpha (q) signalling events
Reactome	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
WikiPathways	GPCRs, Class A Rhodopsin-like
	Incretin Synthesis, Secretion, and Inactivation
	Gastrin-CREB signalling pathway via PKC and MAPK
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541617	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6483).
Ref 532363	Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2013 May 9;4(5):441-445. Epub 2013 Apr 8.

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Drug Information