Drug General Information
Drug ID	D0S0VZ
Former ID	DIB000663
Drug Name	IDRA-21
Synonyms	IDRA-21 analogs; IDRA-5
Drug Type	Small molecular drug
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Terminated	[467553], [527059]
Company	Fidia-Georgetown Institute for the Neurosciences
Structure		Download 2D MOL 3D MOL
Formula	C8H9ClN2O2S
InChI	InChI=1S/C8H9ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-5,10-11H,1H3
InChIKey	VZRNTCHTJRLTMU-UHFFFAOYSA-N
CAS Number	CAS 22503-72-6
PubChem Compound ID	3688
PubChem Substance ID	3153204, 4725772, 8152331, 14798209, 24896078, 26752113, 29222811, 47211774, 47959889, 57321941, 75096882, 85787797, 91704602, 103277548, 103807507, 104304235, 117464560, 118696386, 126407681, 129550235, 135116603, 135156569, 135156570, 135698080, 137102587, 142978078, 143857868, 162022823, 162227378, 162817920, 178101036, 184590059, 226553987, 241182241, 241375306, 252451275
Target and Pathway
Target(s)	Glutamate receptor AMPA subtype	Target Info	Modulator	[527059]
	NMDA receptor	Target Info	Modulator	[527059]
References
Ref 467553	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4219).
Ref 527059	IDRA-21, a positive AMPA receptor modulator, inhibits synaptic and extrasynaptic NMDA receptor mediated events in cultured cerebellar granule cells. Neuropharmacology. 2004 Jun;46(8):1105-13.
Ref 527059	IDRA-21, a positive AMPA receptor modulator, inhibits synaptic and extrasynaptic NMDA receptor mediated events in cultured cerebellar granule cells. Neuropharmacology. 2004 Jun;46(8):1105-13.

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