Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0S1XO
|
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| Former ID |
DIB002185
|
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| Drug Name |
BIBX-79
|
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| Drug Type |
Small molecular drug
|
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| Indication | Arteriosclerosis [ICD9: 440; ICD10:I70] | Terminated | [1] | ||
| Company |
Boehringer Ingelheim Corp
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C23H29ClN2O
|
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| Canonical SMILES |
C(=O)(N([C@@H]1CC[C@@H](c2ccc(CN(C)C)cc2)CC1)C)c1ccc(cc<br />1)Cl
|
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| CAS Number |
CAS 175033-26-8
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Lanosterol synthase | Target Info | Modulator | [2], [1] | |
| BioCyc Pathway | Cholesterol biosynthesis II (via 24,25-dihydrolanosterol) | ||||
| Cholesterol biosynthesis III (via desmosterol) | |||||
| Cholesterol biosynthesis I | |||||
| Superpathway of cholesterol biosynthesis | |||||
| Lanosterol biosynthesis | |||||
| KEGG Pathway | Steroid biosynthesis | ||||
| Metabolic pathways | |||||
| Biosynthesis of antibiotics | |||||
| PANTHER Pathway | Cholesterol biosynthesis | ||||
| PathWhiz Pathway | Steroid Biosynthesis | ||||
| Reactome | Cholesterol biosynthesis | ||||
| Activation of gene expression by SREBF (SREBP) | |||||
| WikiPathways | Activation of Gene Expression by SREBP (SREBF) | ||||
| SREBP signalling | |||||
| Cholesterol Biosynthesis | |||||
| Cholesterol biosynthesis | |||||
| References | |||||
| REF 1 | Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells. J Lipid Res. 1996 Jan;37(1):148-58. | ||||
| REF 2 | Toxicologic lesions associated with two related inhibitors of oxidosqualene cyclase in the dog and mouse. Toxicol Pathol. 2001 Mar-Apr;29(2):174-9. | ||||
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