Drug General Information
Drug ID	D0S4LN
Former ID	DNC014560
Drug Name	(3-Amino-propyl)-difluoromethyl-phosphinic acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533678]
Structure		Download 2D MOL
Formula	C4H10F2NO2P
Canonical SMILES	C(CN)CP(=O)(C(F)F)O
InChI	1S/C4H10F2NO2P/c5-4(6)10(8,9)3-1-2-7/h4H,1-3,7H2,(H,8,9)
InChIKey	TXAHGWWWANKBDA-UHFFFAOYSA-N
PubChem Compound ID	10154248
Target and Pathway
Target(s)	Gamma-aminobutyric acid B receptor	Target Info	Inhibitor	[533678]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	GABAergic synapse
	Estrogen signaling pathway
	Morphine addiction
Reactome	Activation of G protein gated Potassium channels
	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Potassium Channels
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 533678	J Med Chem. 1995 Aug 18;38(17):3297-312.Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists.
Ref 533678	J Med Chem. 1995 Aug 18;38(17):3297-312.Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists.

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