Drug Information

Drug General Information
Drug ID
D0S4LV
Former ID
DNCL002498
Drug Name
VB-111
Indication Glioblastoma multiforme [ICD9: 191; ICD10:C71] Phase 2 [531640]
Company
VBL Therapeutics
Target and Pathway
Target(s) CD95 Target Info Modulator
Tumour necrosis factor receptor-1 (TNFR1) Target Info Modulator
KEGG Pathway MAPK signaling pathway
Cytokine-cytokine receptor interaction
p53 signaling pathway
Apoptosis
Natural killer cell mediated cytotoxicity
TNF signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Type I diabetes mellitus
Alzheimer's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Hepatitis B
Measles
Influenza A
Herpes simplex infection
Pathways in cancer
Proteoglycans in cancer
Autoimmune thyroid disease
Allograft rejection
Graft-versus-host diseasehsa04010:MAPK signaling pathway
NF-kappa B signaling pathway
Sphingolipid signaling pathway
Osteoclast differentiation
Adipocytokine signaling pathway
Amyotrophic lateral sclerosis (ALS)
Toxoplasmosis
Tuberculosis
Hepatitis C
HTLV-I infection
NetPath Pathway IL2 Signaling Pathway
TCR Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
FAS signaling pathway
p53 pathwayP00006:Apoptosis signaling pathway
Pathway Interaction Database p73 transcription factor network
FAS (CD95) signaling pathway
Direct p53 effectors
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Caspase Cascade in Apoptosis
Validated transcriptional targets of TAp63 isoformsnfkappabcanonicalpathway:Canonical NF-kappaB pathway
Signaling events mediated by HDAC Class I
TNF receptor signaling pathway
Ceramide signaling pathway
Reactome FasL/ CD95L signalingR-HSA-5357786:TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production
TNFs bind their physiological receptors
TNF signaling
WikiPathways DNA Damage Response
TCR Signaling Pathway
Apoptosis Modulation by HSP70
MAPK Signaling Pathway
FAS pathway and Stress induction of HSP regulation
Apoptosis
Integrated Pancreatic Cancer Pathway
Adipogenesis
Allograft Rejection
Alzheimers Disease
Extrinsic Pathway for Apoptosis
Apoptosis Modulation and Signaling
miRNA Regulation of DNA Damage ResponseWP453:Inflammatory Response Pathway
Cardiac Hypertrophic Response
Nanoparticle triggered regulated necrosis
Amyotrophic lateral sclerosis (ALS)
TNF alpha Signaling Pathway
References
Ref 531640VB-111 for cancer. Expert Opin Biol Ther. 2011 Dec;11(12):1669-76.

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