| Drug General Information |
| Drug ID |
D0S6TW
|
| Former ID |
DNC012461
|
| Drug Name |
6,7-Dichloro-1,4-dihydro-quinoxaline-2,3-dione
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
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| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C8H4Cl2N2O2
|
| Canonical SMILES |
C1=C2C(=CC(=C1Cl)Cl)NC(=O)C(=O)N2
|
| InChI |
1S/C8H4Cl2N2O2/c9-3-1-5-6(2-4(3)10)12-8(14)7(13)11-5/h1-2H,(H,11,13)(H,12,14)
|
| InChIKey |
AVBSIKMUAFYZAV-UHFFFAOYSA-N
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| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
NMDA receptor subunit NR1 |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
|
Ras signaling pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Circadian entrainment
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Long-term potentiation
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Glutamatergic synapse
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Alzheimer's disease
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Amyotrophic lateral sclerosis (ALS)
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Huntington's disease
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Cocaine addiction
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Amphetamine addiction
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Nicotine addiction
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Alcoholism
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PANTHER Pathway
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Huntington disease
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Ionotropic glutamate receptor pathway
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Metabotropic glutamate receptor group III pathway
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Metabotropic glutamate receptor group I pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
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Reactome
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EPHB-mediated forward signaling
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Unblocking of NMDA receptor, glutamate binding and activation
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CREB phosphorylation through the activation of CaMKII
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Ras activation uopn Ca2+ infux through NMDA receptor
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RAF/MAP kinase cascade
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WikiPathways
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SIDS Susceptibility Pathways
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Hypothetical Network for Drug Addiction
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Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
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Spinal Cord Injury
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BDNF signaling pathway
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Alzheimers Disease
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| References |
| REF 1 | 1-Hydroxy-1,4-dihydroquinoxaline-2,3-diones: Novel antagonists at NMDA receptor glycine sites, Bioorg. Med. Chem. Lett. 6(4):439-440 (1996). |
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