Drug General Information
Drug ID	D0S6VB
Former ID	DCL000104
Drug Name	DG031
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Discontinued in Phase 3	[1], [2]
Company	DeCODE genetics
Structure		Download 2D MOL 3D MOL
Formula	C23H23NO3
InChIKey	ZEYYDOLCHFETHQ-JOCHJYFZSA-N
PubChem Compound ID	123723
PubChem Substance ID	10240841, 12014729, 14925990, 29303934, 47208315, 50064313, 50860736, 53790803, 57340548, 103298269, 103948956, 104419179, 129893024, 134338795, 135079224, 137133767, 137275911, 140101434, 162784212, 172918191, 178101840, 198972657, 208265309, 223704953, 224973517, 227258571, 241376506, 249617906, 252157339
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenaseactivating protein	Target Info	Inhibitor	[3], [4]
NetPath Pathway	IL4 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	Leptin Signaling Pathway
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
WikiPathways	Nuclear Receptors Meta-Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
REF 1	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5148).
REF 2	FLAP inhibitors for the treatment of inflammatory diseases. Curr Opin Investig Drugs. 2009 Nov;10(11):1163-72.
REF 3	Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial. JAMA. 2005 May 11;293(18):2245-56.
REF 4	BAY x 1005 attenuates atherosclerosis in apoE/LDLR - double knockout mice. J Physiol Pharmacol. 2007 Sep;58(3):583-8.

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