Drug Information

Drug General Information
Drug ID
D0S7JH
Former ID
DNCL001904
Drug Name
Macitentan
Drug Type
Small molecular drug
Indication Cardiovascular disorder [ICD10:I00-I99] Approved [532651], [542373], [551871]
Company
Actelion Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C19H20Br2N6O4S
InChI
InChI=1S/C19H20Br2N6O4S/c1-2-7-26-32(28,29)27-17-16(13-3-5-14(20)6-4-13)18(25-12-24-17)30-8-9-31-19-22-10-15(21)11-23-19/h3-6,10-12,26H,2,7-9H2,1H3,(H,24,25,27)
InChIKey
JGCMEBMXRHSZKX-UHFFFAOYSA-N
PubChem Compound ID
16004692
PubChem Substance ID
24380756, 28680076, 37128307, 135262332, 135626853, 136023841, 139257646, 152256091, 152258558, 160647393, 160703277, 162202062, 163344650, 171572070, 172087019, 172096639, 174007274, 175427162, 178103924, 184815478, 189628674, 198971703, 198993773, 223385903, 223701845, 223705199, 227656403, 241382239, 242590074, 248261348, 249867527, 250225136, 252069311, 252110242, 252166931, 252225701, 252437394, 252451827
SuperDrug ATC ID
C02KX04
Target and Pathway
Target(s) Endothelin-1 receptor Target Info Modulator [532651]
Endothelin B receptor Target Info Modulator [532651]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Renin secretion
Pathways in cancerhsa04020:Calcium signaling pathway
Melanogenesis
Pathways in cancer
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Endothelin signaling pathwayP00019:Endothelin signaling pathway
Pathway Interaction Database Endothelins
EGFR-dependent Endothelin signaling eventsendothelinpathway:Endothelins
Arf6 trafficking events
Reactome Peptide ligand-binding receptors
G alpha (q) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP98:Prostaglandin Synthesis and Regulation
References
Ref 5326512013 FDA drug approvals. Nat Rev Drug Discov. 2014 Feb;13(2):85-9.
Ref 542373(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7352).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 5326512013 FDA drug approvals. Nat Rev Drug Discov. 2014 Feb;13(2):85-9.

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