| Drug General Information |
| Drug ID |
D0S7UD
|
| Former ID |
DNC010186
|
| Drug Name |
4-(1H-indol-5-yloxy)-5-styrylnicotinonitrile
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C22H15N3O
|
| Canonical SMILES |
C1=CC=C(C=C1)C=CC2=C(C(=CN=C2)C#N)OC3=CC4=C(C=C3)NC=C4
|
| InChI |
1S/C22H15N3O/c23-13-19-15-24-14-18(7-6-16-4-2-1-3-5-16)22(19)26-20-8-9-21-17(12-20)10-11-25-21/h1-12,14-15,25H/b7-6+
|
| InChIKey |
IMMBFBPNPIRCBR-VOTSOKGWSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
mRNA of Protein kinase C-theta |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
|
NF-kappa B signaling pathway
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Vascular smooth muscle contraction
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Tight junction
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T cell receptor signaling pathway
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Inflammatory mediator regulation of TRP channels
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Adipocytokine signaling pathway
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Measles
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PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
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Angiogenesis
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Apoptosis signaling pathway
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EGF receptor signaling pathway
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Endothelin signaling pathway
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FGF signaling pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
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T cell activation
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VEGF signaling pathway
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Wnt signaling pathway
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5HT2 type receptor mediated signaling pathway
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Histamine H1 receptor mediated signaling pathway
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Oxytocin receptor mediated signaling pathway
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Thyrotropin-releasing hormone receptor signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Endothelins
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TCR signaling in naï
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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TCR signaling in naï
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Thromboxane A2 receptor signaling
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Downstream signaling in naï
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Reactome
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Apoptotic cleavage of cellular proteins
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Effects of PIP2 hydrolysis
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Inactivation, recovery and regulation of the phototransduction cascade
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FCERI mediated NF-kB activation
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G alpha (z) signalling events
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WikiPathways
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TCR Signaling Pathway
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Calcium Regulation in the Cardiac Cell
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Insulin Signaling
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Wnt Signaling Pathway
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Wnt Signaling Pathway and Pluripotency
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G Protein Signaling Pathways
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Myometrial Relaxation and Contraction Pathways
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Fc epsilon receptor (FCERI) signaling
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Corticotropin-releasing hormone
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Signaling Pathways in Glioblastoma
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miRs in Muscle Cell Differentiation
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TCR signaling
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Netrin-1 signaling
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GPCR downstream signaling
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Effects of PIP2 hydrolysis
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Apoptotic execution phase
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32. Epub 2009 Aug 29.First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors. |
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