Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0S8IQ
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| Former ID |
DNC004591
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| Drug Name |
METHACHOLINE
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| Drug Type |
Small molecular drug
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| Formula |
C8H18NO2+
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| InChI |
InChI=1S/C8H18NO2/c1-7(11-8(2)10)6-9(3,4)5/h7H,6H2,1-5H3/q+1
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| InChIKey |
NZWOPGCLSHLLPA-UHFFFAOYSA-N
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| CAS Number |
CAS 55-92-5
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| PubChem Compound ID | |||||
| PubChem Substance ID |
9674, 4560837, 6858025, 8145952, 8151370, 11466787, 11467907, 11486453, 15171020, 29221181, 47291788, 47365857, 47365858, 47960409, 48035799, 48111107, 48111108, 48259911, 49698633, 49868461, 50105267, 57321088, 80531537, 90340728, 99443261, 103105295, 103255467, 103959627, 104299303, 117550978, 124749391, 124879139, 124879140, 126407256, 127303926, 127303927, 127303928, 127303929, 127303930, 128778492, 134341796, 134972446, 137050851, 138551103, 142795339, 160967878, 178104010, 179116773, 226449776, 241097775
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| Target and Pathway | |||||
| Target(s) | Muscarinic acetylcholine receptor M2 | Target Info | Inhibitor | [534645] | |
| Muscarinic acetylcholine receptor M4 | Target Info | Inhibitor | [534645] | ||
| PANTHER Pathway | Alzheimer disease-amyloid secretase pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway | |||||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||||
| PathWhiz Pathway | Muscle/Heart Contraction | ||||
| References | |||||
| Ref 526519 | Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle. Am J Respir Cell Mol Biol. 2003 Feb;28(2):257-62. | ||||
| Ref 530155 | Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells. Eur Respir J. 2009 Dec;34(6):1436-43. | ||||
| Ref 533484 | Dissociation constants and relative efficacies of acetylcholine, (+)- and (-)-methacholine at muscarinic receptors in the guinea-pig ileum. Br J Pharmacol. 1986 Sep;89(1):7-13. | ||||
| Ref 542461 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7438). | ||||
| Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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