Drug Information

Drug General Information
Drug ID
D0S8RD
Former ID
DNC001461
Drug Name
Trecadrine
Drug Type
Small molecular drug
Indication Discovery agent Terminated [545594]
Structure
Download
2D MOL

3D MOL
Formula
C27H29NO
Canonical SMILES
CC(C(C1=CC=CC=C1)O)N(C)CC=C2C3=CC=CC=C3CCC4=CC=CC=C42
InChI
1S/C27H29NO/c1-20(27(29)23-12-4-3-5-13-23)28(2)19-18-26-24-14-8-6-10-21(24)16-17-22-11-7-9-15-25(22)26/h3-15,18,20,27,29H,16-17,19H2,1-2H3
InChIKey
BHVGOYREXHCFOE-UHFFFAOYSA-N
CAS Number
CAS 90845-56-0
PubChem Compound ID
65823
PubChem Substance ID
17187671, 43122565, 57315757, 80936500, 85210207, 104334748, 126423493, 127517840, 134340580, 134340641, 135025194, 172820819, 179323333, 235831297
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [537984]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 545594Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003832)
Ref 537984Potential anti-diabetic applications of a new molecule with affinity for beta 3-adrenoceptors. Life Sci. 1996;59(11):PL141-6.

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