Drug General Information
Drug ID	D0S9OH
Former ID	DNCL002207
Drug Name	L-MDAM
Drug Type	Small molecular drug
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Phase 1	[546152]
Company	BioNumerik Pharmaceuticals
Structure		Download 2D MOL 3D MOL
Formula	C21H21N7O5
PubChem Compound ID	9803852
Target and Pathway
Target(s)	DHFR	Target Info	Inhibitor	[534749]
KEGG Pathway	One carbon pool by folate
	Folate biosynthesis
	Metabolic pathways
PANTHER Pathway	Tetrahydrofolate biosynthesis
	Formyltetrahydroformate biosynthesis
Pathway Interaction Database	E2F transcription factor network
PathWhiz Pathway	Folate Metabolism
	Pterine Biosynthesis
Reactome	E2F mediated regulation of DNA replication
	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
	Metabolism of folate and pterines
	G1/S-Specific Transcription
WikiPathways	Nucleotide Metabolism
	Trans-sulfuration and one carbon metabolism
	Retinoblastoma (RB) in Cancer
	One Carbon Metabolism
	Metabolism of water-soluble vitamins and cofactors
	Metabolism of nitric oxide
	Folate Metabolism
	Fluoropyrimidine Activity
References
Ref 546152	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006614)
Ref 534749	Polyglutamylation of the dihydrofolate reductase inhibitor gamma-methylene-10-deazaaminopterin is not essential for antitumor activity. Clin Cancer Res. 1996 Apr;2(4):707-12.

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