Drug Information

Drug General Information
Drug ID
D0S9SJ
Former ID
DIB020942
Drug Name
SGC0946
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532160]
Structure
Download
2D MOL
Formula
C28H40BrN7O4
InChI
InChI=1S/C28H40BrN7O4/c1-16(2)35(12-6-11-31-27(39)34-18-9-7-17(8-10-18)28(3,4)5)14-20-22(37)23(38)26(40-20)36-13-19(29)21-24(30)32-15-33-25(21)36/h7-10,13,15-16,20,22-23,26,37-38H,6,11-12,14H2,1-5H3,(H2,30,32,33)(H2,31,34,39)/t20-,22-,23-,26-/m1/s1
InChIKey
IQCKJUKAQJINMK-HUBRGWSESA-N
PubChem Compound ID
56962337
PubChem Substance ID
135676607, 160643787, 178103599, 194165848, 194940912, 223705098, 225848235, 241377044, 252158155, 252450563, 252473401
Target and Pathway
Target(s) DOT1L Target Info Inhibitor [532160]
KEGG Pathway Lysine degradation
Transcriptional misregulation in cancer
Reactome PKMTs methylate histone lysines
WikiPathways Histone Modifications
References
Ref 532160Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun. 2012;3:1288.
Ref 532160Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun. 2012;3:1288.

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