Drug Information

Drug General Information
Drug ID
D0S9UT
Former ID
DAP000041
Drug Name
Carmustine
Synonyms
BCNU; Becenum; Becenun; BiCNU; Bischlorethylnitrosourea; Bischlorethylnitrosurea; Bischloroethylnitrosourea; Carmubris; Carmustin; Carmustina; Carmustinum; FIVB; Gliadel; Nitrumon; BCNU [Chloroethyl nitrosoureas]; Bi CNU; Bischloroethyl nitrosourea; Bischloroethyl nitrosourea [Chloroethyl nitrosoureas]; Carmustine in ethanol; Gliadel Wafer; C 0400; DTI 015; FDA 0345; SK 27702; SRI 1720; BiCNU (TN); Bis(chloroethyl)nitrosourea; Carmustina [INN-Spanish]; Carmustinum [INN-Latin]; Bis(2-chloroethyl)nitrosourea; Carmustine (USAN/INN); Carmustine [USAN:INN:BAN]; Bis(2-chloroethyl)1-nitrosourea; Bis-N,N'-(chloroethyl)nitrosourea; Gliadel, BCNU, NSC-409962, Becenun, Carmustine; N,N'-BIS(2-CHLOROETHYL)-N-NITROSOUREA; 1,3-BIS(CHLOROETHYL)-1-NITROSOUREA; 1,3-Bis(2-chloroethyl)-1-nitrosourea; 1,3-Bis(2-chloroethyl)nitrosourea; 1,3-Bis(beta-chloroethyl)-1-nitrosourea; 1,3-Bis(beta.-chloroethyl)-1-nitrosourea
Drug Type
Small molecular drug
Indication Brain cancer [ICD9: 191, 225.0; ICD10:C71, D33] Approved [538486], [541883]
Therapeutic Class
Anticancer Agents
Company
Bristol-Myers Squibb.
Structure
Download
2D MOL

3D MOL
Formula
C5H9Cl2N3O2
InChI
InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
InChIKey
DLGOEMSEDOSKAD-UHFFFAOYSA-N
CAS Number
CAS 154-93-8
PubChem Compound ID
2578
PubChem Substance ID
9090, 479311, 596507, 7387279, 7847320, 7978864, 8149911, 8151703, 10321906, 11110902, 11336010, 11361249, 11363159, 11365721, 11368283, 11374435, 11376445, 11408323, 11462221, 11492703, 11494079, 11533494, 15171986, 17404751, 24278289, 26679572, 26747453, 26753530, 29221738, 46506980, 47291180, 47736530, 48334542, 48415703, 49855055, 50105925, 50105926, 50283817, 53777294, 53788727, 56313669, 57264377, 57321380, 71821585, 81092866, 85230955, 90341293, 92303547, 92307712, 92710002
ChEBI ID
ChEBI:3423
SuperDrug ATC ID
L01AD01
SuperDrug CAS ID
cas=000154938
Target and Pathway
Target(s) Human DNA Target Info Modulator [528163]
References
Ref 538486FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 017422.
Ref 541883(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6800).
Ref 528163Carmustine-induced toxicity, DNA crosslinking and O6-methylguanine-DNA methyltransferase activity in two human lung cancer cell lines. Eur J Cancer. 1991;27(12):1658-62.

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