Drug Information

Drug General Information
Drug ID
D0S9XV
Former ID
DIB003473
Drug Name
A-134974
Drug Type
Small molecular drug
Indication Epilepsy [ICD10:G40] Terminated [468194], [546592]
Company
Abbott Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C11H14IN5O2
InChI
InChI=1S/C11H14IN5O2/c12-4-2-17(6-1-5(13)8(18)9(6)19)11-7(4)10(14)15-3-16-11/h2-3,5-6,8-9,18-19H,1,13H2,(H2,14,15,16)/t5-,6+,8+,9-/m0/s1
InChIKey
NSXJHIFQIZKLGF-LWIVVEGESA-N
CAS Number
CAS 186141-75-3
PubChem Compound ID
9885936
PubChem Substance ID
14853301, 24172553, 45632876, 47588804, 76735115, 90341626, 124958361, 178101822
Target and Pathway
Target(s) Adenosine kinase Target Info Inhibitor [525955]
BioCyc Pathway Superpathway of purine nucleotide salvage
Adenine and adenosine salvage II
KEGG Pathway Purine metabolism
Metabolic pathways
Reactome Purine salvage
WikiPathways Metabolism of nucleotides
References
Ref 468194(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5130).
Ref 546592Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009094)
Ref 525955Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action. J Pharmacol Exp Ther. 2001Feb;296(2):501-9.

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