Drug Information

Drug General Information
Drug ID
D0SH3I
Former ID
DAP001318
Drug Name
Bortezomib
Synonyms
DPBA; PROSCRIPT BORONIC ACID; LPD 341; LDP-341; LPD-341; PS-341; VELCADE (TN); Velcade (TN); Pyz-Phe-boroLeu; Bortezomib(JAN/USAN/INN); Velcade, MG-341, PS-341, Bortezomib; [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid; N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE; N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide; Bortezomib (Proteasome inhibitor)
Drug Type
Small molecular drug
Indication Multiple myeloma [ICD9: 203; ICD10:C90] Approved [537129], [541528]
Non-hodgkin's lymphoma; Mantle cell lymphoma [ICD10:C859, C85] Phase 3 [537129], [541528]
Therapeutic Class
Anticancer Agents
Company
Takeda
Structure
Download
2D MOL

3D MOL
Formula
C19H25BN4O4
InChI
InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
InChIKey
GXJABQQUPOEUTA-RDJZCZTQSA-N
CAS Number
CAS 179324-69-7
PubChem Compound ID
387447
PubChem Substance ID
518755, 600019, 10276517, 11433362, 12015194, 14853748, 17137090, 17397304, 46508736, 50726119, 53787350, 56311715, 56311812, 56312401, 56313329, 56314055, 56314414, 56314469, 56314470, 57402302, 85096715, 87325438, 91611228, 99432365, 99443946, 103338073, 103963945, 104603020, 118048485, 118318599, 121360388, 124756934, 124950705, 125163741, 134340388, 135696579, 136023422, 136342479, 136367512, 136920302, 137030372, 141858114, 143497187, 144206183, 144206225, 152049125, 152239004, 152344341, 160829216, 160968549
ChEBI ID
ChEBI:52717
SuperDrug ATC ID
L01XX32
SuperDrug CAS ID
cas=179324697
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Proteasome Target Info Modulator [556264]
References
Ref 537129New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21.
Ref 541528(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6391).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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