Drug Information

Drug General Information
Drug ID
D0SJ2Q
Former ID
DNC006677
Drug Name
OLEANOLIC_ACID
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540267]
Structure
Download
2D MOL

3D MOL
Formula
C30H48O3
InChI
InChI=1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,23-,27-,28+,29+,30-/m0/s1
InChIKey
MIJYXULNPSFWEK-GTOFXWBISA-N
PubChem Compound ID
10494
PubChem Substance ID
411432, 606099, 8140048, 8157593, 12013877, 14931343, 16612754, 22396103, 24898021, 26725302, 29204449, 29228987, 48483988, 49999299, 53253218, 53788193, 57326261, 57654491, 85297334, 92298723, 92465252, 92711005, 93576683, 96023600, 103324264, 104082596, 104323458, 118048745, 124558746, 124800067, 125312644, 126524541, 126631301, 126657657, 126664253, 128600272, 134343882, 134976838, 136353287, 137006891, 137186946, 142252735, 152090835, 162223020, 163614423, 164786710, 175267875, 175607979, 178100342, 179150511
Target and Pathway
Target(s) mRNA of Protein tyrosine phosphatase-1B Target Info Inhibitor [530332]
Glycogen phosphorylase, muscle form Target Info Inhibitor [529507]
DNA polymerase Target Info Inhibitor [525684]
BioCyc Pathway Glycogenolysis
KEGG Pathway Adherens junction
Insulin signaling pathwayhsa00500:Starch and sucrose metabolism
Metabolic pathways
Insulin signaling pathway
Glucagon signaling pathway
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Cadherin signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway Interaction Database Insulin Pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by PTP1B
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by TCPTP
IGF1 pathway
EGF receptor (ErbB1) signaling pathway
Posttranslational regulation of adherens junction stability and dissassembly
PDGFR-beta signaling pathway
N-cadherin signaling events
Reactome Integrin alphaIIb beta3 signaling
Regulation of IFNG signaling
Regulation of IFNA signaling
Growth hormone receptor signaling
WikiPathways Insulin Signaling
Growth hormone receptor signaling
Leptin signaling pathway
Interferon gamma signaling
Interferon alpha/beta signaling
Integrin alphaIIb beta3 signalingWP500:Glycogen Metabolism
Metabolism of carbohydrates
References
Ref 540267(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3306).
Ref 525684J Nat Prod. 1999 Dec;62(12):1624-6.DNA polymerase beta inhibitors from Baeckea gunniana.
Ref 529507J Med Chem. 2008 Jun 26;51(12):3540-54. Epub 2008 Jun 3.Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.
Ref 530332J Nat Prod. 2009 Sep;72(9):1620-6.Chemical Constituents of the Roots of Euphorbia micractina.

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