Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0SM8S
|
||||
| Former ID |
DNCL002030
|
||||
| Drug Name |
Lebrikizumab
|
||||
| Synonyms |
RG3637
|
||||
| Drug Type |
Monoclonal antibody
|
||||
| Company |
Aerovance
|
||||
| CAS Number |
CAS 953400-68-5
|
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| Target and Pathway | |||||
| Target(s) | Interleukin-13 | Target Info | Modulator | [889443] | |
| PANTHER Pathway | Interleukin signaling pathway | ||||
| Pathway Interaction Database | Glucocorticoid receptor regulatory network | ||||
| IL12 signaling mediated by STAT4 | |||||
| PathWhiz Pathway | Fc Epsilon Receptor I Signaling in Mast Cells | ||||
| References | |||||
| Ref 524323 | ClinicalTrials.gov (NCT01875003) A Study of Lebrikizumab in Adolescent Patients With Uncontrolled Asthma Who Are on Inhaled Corticosteroids and a Second Controller Medication. U.S. National Institutes of Health. | ||||
| Ref 542664 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7684). | ||||
| Ref 889356 | ClinicalTrials.gov (NCT00930163) A Study of Lebrikizumab (MILR1444A) in Adult Patients With Asthma Who Are Inadequately Controlled on Inhaled Corticosteroids | ||||
| Ref 889357 | ClinicalTrials.gov (NCT00971035) A Study to Evaluate Lebrikizumab (MILR1444A) in Adult Patients With Asthma Who Are Not Taking Inhaled Corticosteroids | ||||
| Ref 889387 | ClinicalTrials.gov (NCT01987492) A Study of Lebrikizumab (RO5490255) in Participants With Severe Oral Corticosteroids (OCS) Dependent Asthma | ||||
| Ref 889415 | ClinicalTrials.gov (NCT02546700) A Study to Evaluate Safety and Efficacy of Lebrikizumab in Participants With Chronic Obstructive Pulmonary Disease (COPD) | ||||
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