Drug General Information
Drug ID	D0ST5P
Former ID	DIB000411
Drug Name	TA-5538
Synonyms	IDDBCP232835
Indication	Overactive bladder disorder [ICD9: 188, 596.51; ICD10:C67, N32.81]		Discontinued in Phase 2	[548065]
Company	Tanabe Seiyaku Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	N1([C@H](C[C@H](CC1)OC(=O)NCCO)c1c(cc(cc1)F)C)C(=O)N(C)<br />Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Antagonist	[548066]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 548065	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021639)
Ref 548066	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021639)

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