Drug General Information
Drug ID	D0T0BS
Former ID	DIB000577
Drug Name	CGS-18102A
Synonyms	CGP-50281; CGS-18102
Drug Type	Small molecular drug
Indication	Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42]		Terminated	[545030]
Company	Novartis AG
Structure		Download 2D MOL 3D MOL
Formula	C16H24ClNO2
Canonical SMILES	[C@H]12c3c(OC[C@@H]1N(CCC2)CCC)cccc3OC.Cl
CAS Number	CAS 100746-36-9
PubChem Compound ID	146963
Target and Pathway
Target(s)	5-hydroxytryptamine 1A receptor	Target Info	Modulator	[526784]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545030	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001927)
Ref 526784	Quantitative determination of CGS 18102A, a new anxiolytic, in human plasma using capillary gas chromatography/mass spectrometry. Biomed Chromatogr. 1992 Sep-Oct;6(5):244-7.

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