Drug Information

Drug General Information
Drug ID
D0T0LU
Former ID
DAP000818
Drug Name
Conjugated Estrogens
Synonyms
Carentil; Climarest; Congest; Dagynil; Estroplus; Evex; Femavit; Menotabs; Oestrofeminal; Oestrogen; Prelestrin; Premarin; Presomen; Presomil; Progens; Transannon; Conjugated Equine Estrogens; Conjugated Estrogenic Substances; Conjugated estrogenic hormones; Conjugated oestrogens; Conjugated oestrogens [Steroidal oestrogens]; Estrogens conjugated; Par Estro; Steroidal estrogens; ASTA Medica Brand of Estrogens, Conjugated; Almirall Brand of Estrogens, Conjugated; Equine Estrogens, Conjugated; Estro-Feminal; Estrogenic Hormones, Conjugated; Estrogenic substances, conjugated; Estrogens, Conjugated; Estrogens, conjugated USP; Estrogens, conjugated [USP]; Estrogens, conjugated synthetic A; Estrogens, steroidal; Estrone, hydrogen sulfate sodium salt; Oestro-feminal; Sodium estrone 3-monosulfate; Solvay Brand of Estrogens, Conjugated; Trianon Brand of Estrogens, Conjugated; Wyeth Brand of Estrogens, Conjugated; Estrogens, conjugated (USP); Estrogens, conjugated-equine; Mack Brand of Estrogens, Conjugated (USP); Major Brand of Estrogens, Conjugated (USP); Pasadena Brand of Estrogens, Conjugated (USP); Pharmacia Brand of Estrogens, Conjugated (USP); C.E.S.; Estra-1,3,5(10)-trien-17-one, 3-(sulfooxy)-, sodium salt; Sodium [(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate
Drug Type
Small molecular drug
Indication Vasomotor symptoms [ICD9: 627.2; ICD10:N95.1] Approved [529091], [536361]
Therapeutic Class
Estrogens
Company
Wyeth Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C18H22NaO5S+
Canonical SMILES
CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)O.[Na+]
InChI
1S/C18H22O5S.Na/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);/q;+1/t14-,15-,16+,18+;/m1./s1
InChIKey
VUCAHVBMSFIGAI-ZFINNJDLSA-N
CAS Number
CAS 438-67-5
PubChem Compound ID
5351489
PubChem Substance ID
541403, 8138021, 57361384, 80236169, 113904620, 126677587
ChEBI ID
ChEBI:8389
SuperDrug ATC ID
G03CA57
Target and Pathway
Target(s) Estrogen receptor beta Target Info Antagonist [535660], [536952]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Pathway Interaction Database Plasma membrane estrogen receptor signaling
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
Reactome Nuclear Receptor transcription pathway
WikiPathways SIDS Susceptibility Pathways
Ovarian Infertility Genes
Integrated Pancreatic Cancer Pathway
Nuclear Receptors
References
Ref 529091Roles of hormone replacement therapy and iron in proliferation of breast epithelial cells with different estrogen and progesterone receptor status. Breast. 2008 Apr;17(2):172-9. Epub 2007 Oct 24.
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 535660Knockouts model the 100 best-selling drugs--will they model the next 100? Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
Ref 536952Differential biochemical and cellular actions of Premarin estrogens: distinct pharmacology of bazedoxifene-conjugated estrogens combination. Mol Endocrinol. 2009 Jan;23(1):74-85. Epub 2008 Nov 26.

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