Drug Information

Drug General Information
Drug ID
D0T1XW
Former ID
DAP000795
Drug Name
Meclizine
Synonyms
Ancolan; Ancolon; Antivert; Bonadettes; Bonine; Calmonal; Chiclida; Diadril; Histamethine; Histamethizine; Histametizine; Histametizyn; Histametizyne; Itinerol; Marex; Meclicot; Meclozina; Meclozine; Meclozinum; Medivert; Monamine; Navicalm; Nevidoxine; Parachloramine; Peremesin; Postafene; Ravelon; Sabari; Siguran; Subari; Suprimal; Travelon; Veritab; Vomisseis; Vomissels; Dramamine II; Meclizine Hcl; UCB 170; UCB 5052; UCB 5062; Antivert (TN); Antivert/25; Antivert/50; Bonamine (TN); Bonine (TN); Dramamine (TN); Meclizine [INN:BAN]; Meclozina [INN-Spanish]; Meclozine (BAN); Meclozinum [INN-Latin]; Neo-istafene; Neo-suprimal; Neo-suprimel; Nevidoxine (TN); Postafen (TN); Sea-Legs; Ru-Vert-M; U. C. B. 5062; U.C.B. 5062; (+-)-Meclizine; 1-((4-Chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)piperazine; 1-(p-Chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)piperazine; 1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine; 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine; 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)piperazine; 1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine; 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine; 1-p-Chlorobenzhydryl-4-m-methylbenzylpiperazine
Drug Type
Small molecular drug
Indication Nausea; Vomiting; Dizziness [ICD10:R11] Approved [551871]
Therapeutic Class
Antiallergic Agents
Company
Citron Pharma Llc
Structure
Download
2D MOL

3D MOL
Formula
C25H27ClN2
InChI
InChI=1S/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H3
InChIKey
OCJYIGYOJCODJL-UHFFFAOYSA-N
CAS Number
CAS 569-65-3
PubChem Compound ID
4034
PubChem Substance ID
9327, 442158, 4782133, 7979876, 8152525, 10527723, 11335582, 11360821, 11363785, 11366347, 11368909, 11371549, 11373612, 11377071, 11461793, 11466485, 11467605, 11483836, 11486209, 11487926, 11490301, 11491852, 11494705, 14805236, 29223145, 46507782, 47440184, 47515252, 47810681, 47959664, 48035039, 48110390, 48334421, 48416201, 49698867, 50012193, 50807781, 57322105, 76715647, 85209822, 85788825, 96024853, 103604960, 104305237, 117409993, 124883625, 124883627, 125312386, 125823630, 126689207
SuperDrug ATC ID
R06AE05
SuperDrug CAS ID
cas=000569653
Target and Pathway
Target(s) Orphan nuclear receptor NR1I3 Target Info Modulator [536227]
Pathway Interaction Database Glucocorticoid receptor regulatory network
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Constitutive Androstane Receptor Pathway
Drug Induction of Bile Acid Pathway
Nuclear Receptors
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536227Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). Drug Metab Rev. 2006;38(1-2):51-73.

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