Drug Information

Drug General Information
Drug ID
D0T2EO
Former ID
DIB016344
Drug Name
MAXY-4
Synonyms
ASP-2408; CTLA4-Ig proteins (rheumatoid arthritis), Maxygen
Indication Autoimmune diabetes [ICD10:E08-E13] Phase 1 [524627]
Company
Maxygen Inc
Target and Pathway
Target(s) T-lymphocyte activation antigen CD86 Target Info Inhibitor [531427]
T-lymphocyte activation antigen CD80 Target Info Inhibitor [531427]
KEGG Pathway Cell adhesion molecules (CAMs)
Toll-like receptor signaling pathway
Intestinal immune network for IgA production
Type I diabetes mellitus
Transcriptional misregulation in cancer
Autoimmune thyroid disease
Systemic lupus erythematosus
Rheumatoid arthritis
Allograft rejection
Graft-versus-host disease
Viral myocarditishsa04514:Cell adhesion molecules (CAMs)
Viral myocarditis
NetPath Pathway TCR Signaling Pathway
IL3 Signaling Pathway
IL4 Signaling Pathway
RANKL Signaling PathwayNetPath_22:Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway T cell activationP00053:T cell activation
Pathway Interaction Database TCR signaling in na&#xef
TCR signaling in na&#xef
IL12 signaling mediated by STAT4tcr_pathway:TCR signaling in na&#xef
IL12 signaling mediated by STAT4
Reactome PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signalingR-HSA-1257604:PIP3 activates AKT signaling
CTLA4 inhibitory signaling
WikiPathways Toll-like receptor signaling pathway
Inflammatory Response Pathway
IL-3 Signaling Pathway
PIP3 activates AKT signaling
Allograft Rejection
Costimulation by the CD28 family
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Primary Focal Segmental Glomerulosclerosis FSGS
Regulation of toll-like receptor signaling pathway
References
Ref 524627ClinicalTrials.gov (NCT02052375) A Study To Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of ASP2408 After Multiple Dose Subcutaneous Injections in Patients With RheumatoidArthritis on Methotrexate. U.S. National Institutes of Health.
Ref 531427Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science. 2011 Apr 29;332(6029):600-3.

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