Drug General Information
Drug ID	D0T3AW
Former ID	DIB001556
Drug Name	Antroquinonol
Synonyms	Hocena; Fungal extract (cancer), Golden Biotechnology
Indication	Non-small cell lung cancer [ICD10:C33-C34]		Phase 2	[524616]
Company	Golden biotechnology
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C1(=O)C(=C([C@@H]([C@@H]([C@H]1C)C/C=C(/CC/C=C(/CCC=C(C<br />)C)\C)\C)O)OC)OC
CAS Number	CAS 1010081-09-0
Target and Pathway
Target(s)	DNMT1	Target Info	Inhibitor	[532758]
KEGG Pathway	Cysteine and methionine metabolism
	Metabolic pathways
	MicroRNAs in cancer
Pathway Interaction Database	Regulation of retinoblastoma protein
PathWhiz Pathway	Methionine Metabolism
Reactome	PRC2 methylates histones and DNA
	NoRC negatively regulates rRNA expression
	DNA methylation
WikiPathways	Trans-sulfuration and one carbon metabolism
	Retinoblastoma (RB) in Cancer
	One Carbon Metabolism
	Trans-sulfuration pathway
References
Ref 524616	ClinicalTrials.gov (NCT02047344) Efficacy, Safety and Pharmacokinetics Study of Antroquinonol to Treat NSCLC. U.S. National Institutes of Health.
Ref 532758	Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential. J Agric Food Chem. 2014 Jun 18;62(24):5625-35.

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