Drug Information

Drug General Information
Drug ID
D0T3DG
Former ID
DNCL001926
Drug Name
BCI-632
Drug Type
Small molecular drug
Indication Alzheimer disease; Major depressive disorder [ICD9: 331, 296.2, 296.3, 710.0; ICD10:G30, F32, F33, M32] Phase 1 [523828]
Company
BrainCells
Structure
Download
2D MOL

3D MOL
Formula
C15H14Cl2FNO5
Canonical SMILES
C1C2C(C2(C(=O)O)F)C(C1OCC3=CC(=C(C=C3)Cl)Cl)(C(=O)O)N
InChI
1S/C15H14Cl2FNO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1
InChIKey
LFAGGDAZZKUVKO-JAGWWQSPSA-N
PubChem Compound ID
9886034
PubChem Substance ID
14853417, 16465579, 24172633, 45632974, 74583023, 99431575, 103454892, 104039613, 135650605, 138071213, 162222708, 223946634, 226586066, 246470621
Target and Pathway
Target(s) Metabotropic glutamate receptor3 Target Info Modulator [1572591]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 523828ClinicalTrials.gov (NCT01548703) A Multiple Ascending Dose Study of BCI-838 in Healthy Volunteers. U.S. National Institutes of Health.
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.