Drug Information

Drug General Information
Drug ID
D0T3EV
Former ID
DIB002568
Drug Name
SR-146131
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Discontinued in Phase 1 [543241], [546817]
Company
Sanofi-Synthelabo
Structure
Download
2D MOL

3D MOL
Formula
C32H36ClN3O5S
InChI
InChI=1S/C32H36ClN3O5S/c1-18-12-19(2)30-21(13-18)14-24(36(30)17-28(37)38)31(39)35-32-34-29(22-15-26(41-4)23(33)16-25(22)40-3)27(42-32)11-10-20-8-6-5-7-9-20/h12-16,20H,5-11,17H2,1-4H3,(H,37,38)(H,34,35,39)
InChIKey
NFDFTMICKVDYLQ-UHFFFAOYSA-N
CAS Number
CAS 221671-61-0
PubChem Compound ID
9852833
PubChem Substance ID
14911992, 24148074, 45275151, 79343389, 85209315, 124954272, 135651076, 137151659, 225101527, 227262478, 242652806, 248760864
Target and Pathway
Target(s) Cholecystokinin receptor type A Target Info Agonist [525475]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Insulin secretion
Pancreatic secretion
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543241(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 868).
Ref 546817Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010439)
Ref 525475SR146131: a new potent, orally active, and selective nonpeptide cholecystokinin subtype 1 receptor agonist. I. In vitro studies. J Pharmacol Exp Ther. 1999 May;289(2):742-51.

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