Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0T3JW
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| Former ID |
DCL001028
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| Drug Name |
U-99194A
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| Synonyms |
Pnu 99194A; U 99194; U 99194A; PNU-99194A; U-99194; (5,6-dimethoxyindan-2-yl)dipropylamine; 1H-Indan-2-amine, 2,3-dihydro-5,6-dimethoxy-N,N-dipropyl-, hydrochloride; 1H-Inden-2-amine, 2,3-dihydro-5,6-dimethoxy-N,N-dipropyl-, hydrochloride; 5,6-Dimethoxy-2-(dipropylamino)indan hydrochloride; 5,6-Dimethoxy-N,N-dipropyl-2,3-dihydro-1H-indan-2-amine; 5,6-Dimethoxy-N,N-dipropyl-2,3-dihydro-1H-inden-2-amine hydrochloride; 5,6-dimethoxy-2-(di-n-propylamino)indan; 5,6-dimethoxy-n,n-dipropyl-2,3-dihydro-1h-inden-2-amine hydrochloride(1:1)
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| Drug Type |
Small molecular drug
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| Indication | Schizophrenia [ICD9: 295; ICD10:F20] | Preclinical | [1] | ||
| Company |
Pfizer
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| Structure |
|
Download2D MOL |
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| Formula |
C17H28ClNO2
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| Canonical SMILES |
CCCN(CCC)C1CC2=CC(=C(C=C2C1)OC)OC.Cl
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| InChI |
1S/C17H27NO2.ClH/c1-5-7-18(8-6-2)15-9-13-11-16(19-3)17(20-4)12-14(13)10-15;/h11-12,15H,5-10H2,1-4H3;1H
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| InChIKey |
NMBUOXDBNWBGIM-UHFFFAOYSA-N
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| CAS Number |
CAS 83598-46-3
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| SuperDrug ATC ID |
H01BA02
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| SuperDrug CAS ID |
cas=016679586
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| Target and Pathway | |||||
| Target(s) | D(3) dopamine receptor | Target Info | Binder | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Dopaminergic synapse | |||||
| Reactome | Dopamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| Nicotine Activity on Dopaminergic Neurons | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31. | ||||
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