Drug Information

Drug General Information
Drug ID
D0T3KI
Former ID
DAP000890
Drug Name
Naratriptan
Synonyms
Colatan; Naramig; Naratriptanum; Amerge (TN); Naramig (TN); Naratriptan (INN); Amerge, Naramig,Naratriptan; N-methyl-2-(3-(1-methylpiperiden-4-yl)indole-5-yl)ethanesulfonamide; N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide; N-methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]-ethanesulfonamide
Drug Type
Small molecular drug
Indication Migraine headaches [ICD9: 346; ICD10:G43] Approved [467741], [536361]
Therapeutic Class
Vasoconstrictor Agents
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C17H25N3O2S
InChI
InChI=1S/C17H25N3O2S/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14/h3-4,11-12,14,18-19H,5-10H2,1-2H3
InChIKey
AMKVXSZCKVJAGH-UHFFFAOYSA-N
CAS Number
CAS 121679-13-8
PubChem Compound ID
4440
PubChem Substance ID
9994, 591979, 4406062, 7980085, 8152740, 14802133, 29223537, 46507243, 46530540, 48416313, 49984092, 50126335, 50340505, 57322272, 85209198, 92721601, 93166470, 96024943, 103396287, 103966995, 104306415, 118043420, 124757290, 125001918, 125164094, 125339313, 126619011, 126661482, 126731399, 127427940, 134221895, 134338167, 135035417, 135650691, 135692164, 137002440, 139157587, 143500462, 144116266, 152035273, 152253555, 152344169, 160964291, 164830541, 174006312, 175268422, 176253695, 179116807, 196105283, 210279333
ChEBI ID
ChEBI:7478
SuperDrug ATC ID
N02CC02
SuperDrug CAS ID
cas=121679138
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Agonist [536607]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 467741(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 45).
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 536607Triptans in pregnancy. Ther Drug Monit. 2008 Feb;30(1):5-9.

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