Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0T3KI
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| Former ID |
DAP000890
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| Drug Name |
Naratriptan
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| Synonyms |
Colatan; Naramig; Naratriptanum; Amerge (TN); Naramig (TN); Naratriptan (INN); Amerge, Naramig,Naratriptan; N-methyl-2-(3-(1-methylpiperiden-4-yl)indole-5-yl)ethanesulfonamide; N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide; N-methyl-2-[3-(1-methyl-4-piperidyl)-1H-indol-5-yl]-ethanesulfonamide
|
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| Drug Type |
Small molecular drug
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| Indication | Migraine headaches [ICD9: 346; ICD10:G43] | Approved | [1], [2] | ||
| Therapeutic Class |
Vasoconstrictor Agents
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| Company |
GlaxoSmithKline
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| Structure |
|
Download2D MOL |
|||
| Formula |
C17H25N3O2S
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| InChI |
InChI=1S/C17H25N3O2S/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14/h3-4,11-12,14,18-19H,5-10H2,1-2H3
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| InChIKey |
AMKVXSZCKVJAGH-UHFFFAOYSA-N
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| CAS Number |
CAS 121679-13-8
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| PubChem Compound ID | |||||
| PubChem Substance ID |
9994, 591979, 4406062, 7980085, 8152740, 14802133, 29223537, 46507243, 46530540, 48416313, 49984092, 50126335, 50340505, 57322272, 85209198, 92721601, 93166470, 96024943, 103396287, 103966995, 104306415, 118043420, 124757290, 125001918, 125164094, 125339313, 126619011, 126661482, 126731399, 127427940, 134221895, 134338167, 135035417, 135650691, 135692164, 137002440, 139157587, 143500462, 144116266, 152035273, 152253555, 152344169, 160964291, 164830541, 174006312, 175268422, 176253695, 179116807, 196105283, 210279333
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| ChEBI ID |
ChEBI:7478
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| SuperDrug ATC ID |
N02CC02
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| SuperDrug CAS ID |
cas=121679138
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 1B receptor | Target Info | Agonist | [3] | |
| KEGG Pathway | cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT1 type receptor mediated signaling pathway | |||||
| Reactome | Serotonin receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 45). | ||||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. | ||||
| REF 3 | Triptans in pregnancy. Ther Drug Monit. 2008 Feb;30(1):5-9. | ||||
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