TTD | Drug: D0T4IQ

Drug General Information
Drug ID	D0T4IQ
Former ID	DIB003832
Drug Name	MEN-11149
Indication	Asthma [ICD10:J45]		Terminated	[546726]
Company	The Menarini Group
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(C(=O)N[C@@H]2[C@H](C(=O)N[C@H](N(C(=O)Cc3ccc(cc3)C)C<br />)Cc3cc4c(cc3)cccc4)CCCC2)c[nH]c2c1cccc2
CAS Number	CAS 206052-25-7
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Antagonist	[534597]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546726	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009948)
Ref 534597	Pharmacology of the peptidomimetic, MEN 11149, a new potent, selective and orally effective tachykinin NK1 receptor antagonist. Eur J Pharmacol. 1998 Jan 12;341(2-3):201-9.

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Drug Information