Drug Information

Drug General Information
Drug ID
D0T4SG
Former ID
DCL000460
Drug Name
AZD1981
Drug Type
Small molecular drug
Indication Asthma; Chronic obstructive pulmonary disease [ICD9: 490-492, 493, 494-496; ICD10:J40-J44, J47, J45] Phase 2 [522453], [542660]
Structure
Download
2D MOL

3D MOL
Formula
C19H17ClN2O3S
InChI
InChI=1S/C19H17ClN2O3S/c1-11-19(26-14-8-6-13(20)7-9-14)18-15(21-12(2)23)4-3-5-16(18)22(11)10-17(24)25/h3-9H,10H2,1-2H3,(H,21,23)(H,24,25)
InChIKey
JWYIGNODXSRKGP-UHFFFAOYSA-N
PubChem Compound ID
11292191
PubChem Substance ID
16379833, 23461816, 42371606, 77023806, 136945169, 136961126, 143385079, 172650423, 198939074, 223366015, 224165702, 226088056, 227302200, 242870831, 249755331, 252160766, 252562174
Target and Pathway
Target(s) Putative G-protein coupled receptor 44 Target Info Antagonist [550288]
Reactome Prostanoid ligand receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 522453ClinicalTrials.gov (NCT00766415) 14729-D9831C00002- 1 Month Biopsy Study. U.S. National Institutes of Health.
Ref 542660(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7680).
Ref 550288Clinical pipeline report, company report or official report of AstraZeneca (2009).

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